GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2382817 | 1 | rs10193383 | chr2:219157692 | TMBIM1 | chr2:219138917-219157280:- | 0.13 | 3.93 | 9.11E-5 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| BRCA | cis | rs13424612 | 1 | rs10193610 | chr2:240940618 | NDUFA10 | chr2:240900158-240964798:- | 0.28 | 7.35 | 3.85E-13 | Odorant perception (isobutyraldehyde) |
| BRCA | cis | rs4665058 | 1 | rs10194090 | chr2:160110579 | WDSUB1 | chr2:160092305-160143236:- | 0.33 | 4.08 | 4.81E-5 | Sudden cardiac arrest |
| BRCA | cis | rs4665058 | 1 | rs10196279 | chr2:160116291 | WDSUB1 | chr2:160092305-160143236:- | 0.3 | 3.71 | 0.000215 | Sudden cardiac arrest |
| BRCA | cis | rs4665058 | 1 | rs10199101 | chr2:160081949 | WDSUB1 | chr2:160092305-160143236:- | 0.27 | 3.4 | 0.00069 | Sudden cardiac arrest |
| BRCA | cis | rs6547741 | 1 | rs10205364 | chr2:27794233 | KRTCAP3 | chr2:27665263-27667163:+ | -0.13 | -3.96 | 8.05E-5 | Oral cavity cancer |
| BRCA | cis | rs10205487 | 1 | rs10205487 | chr2:70151471 | ANXA4 | chr2:69969127-70053594:+ | 0.13 | 3.9 | 0.000102 | Carotid plaque burden (smoking interaction) |
| BRCA | cis | rs2382817 | 1 | rs10206064 | chr2:219157959 | GPBAR1 | chr2:219125738-219128582:+ | -0.11 | -3.72 | 0.000208 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| BRCA | cis | rs2382817 | 1 | rs10206064 | chr2:219157959 | TMBIM1 | chr2:219138917-219157280:- | 0.13 | 3.93 | 9.11E-5 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| BRCA | cis | rs13014235 | 1 | rs10206231 | chr2:202229225 | ALS2CR12 | chr2:202153148-202222101:- | -0.2 | -5.17 | 2.76E-7 | Basal cell carcinoma |
| BRCA | cis | rs13014235 | 1 | rs10206231 | chr2:202229225 | PPIL3 | chr2:201735680-201753999:- | -0.15 | -4.09 | 4.59E-5 | Basal cell carcinoma |
| BRCA | cis | rs13424612 | 1 | rs10206993 | chr2:240900919 | NDUFA10 | chr2:240900158-240964798:- | 0.25 | 6.75 | 2.48E-11 | Odorant perception (isobutyraldehyde) |
| BRCA | cis | rs67766926 | 1 | rs10208155 | chr2:61115039 | AHSA2 | chr2:61404553-61414058:+ | -0.12 | -4.93 | 9.69E-7 | Inflammatory skin disease |
| BRCA | cis | rs67766926 | 1 | rs10208155 | chr2:61115039 | C2orf74 | chr2:61372243-61391964:+ | 0.28 | 6.05 | 1.95E-9 | Inflammatory skin disease |
| BRCA | cis | rs6724465 | 1 | rs10208728 | chr2:219917303 | GLB1L | chr2:220101505-220110131:- | -0.2 | -3.66 | 0.000269 | Height |